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Quadrupole-Linear Ion Trap Tandem Mass Spectrometry System for Clinical Biomarker Analysis Article
Xiang Fang, Jie Xie, Shiying Chu, You Jiang, Yuting An, Chang Li, Xiaoyun Gong, Rui Zhai, Zejian Huang, Chunling Qiu, Xinhua Dai
Engineering 2022, Volume 16, Issue 9, Pages 56-64 doi: 10.1016/j.eng.2020.10.021
Keywords: Linear ion trap Quadrupole Space charge effect Collision-induced dissociation Biomarker
A Predictive Instrument for Sensitive and Expedited Measurement of Ultra-Barrier Permeation Article
Jianfeng Wanyan, Kun Cao, Zhiping Chen, Yun Li, Chenxi Liu, Runqing Wu, Xiao-Dong Zhang, Rong Chen
Engineering 2021, Volume 7, Issue 10, Pages 1461-1470 doi: 10.1016/j.eng.2021.02.017
The reliable operation of flexible display devices poses a significant engineering challenge regarding the metrology of high barriers against water vapor. No reliable results have been reported in the range of 10-6 g∙(m2∙d)-1, and there is no standard ultra-barrier for calibration. To detect trace amount of water vapor permeation through an ultra-barrier with extremely high sensitivity and a greatly reduced test period, a predictive instrument was developed by integrating permeation models into high-sensitivity mass spectrometry measurement based on dynamic accumulation, detection, and evacuation of the permeant. Detection reliability was ensured by means of calibration using a standard polymer sample. After calibration, the lower detection limit for water vapor permeation is in the range of 10-7 g∙(m2∙d)-1, which satisfies the ultra-barrier requirement. Predictive permeation models were developed and evaluated using experimental data so that the steady-state permeation rate can be forecasted from non-steady-state results, thus enabling effective measurement of ultra-barrier permeation within a significantly shorter test period.
Keywords: Water vapor permeation Ultra-barrier Predictive model Quadrupole mass spectrometer
Title Author Date Type Operation
Quadrupole-Linear Ion Trap Tandem Mass Spectrometry System for Clinical Biomarker Analysis
Xiang Fang, Jie Xie, Shiying Chu, You Jiang, Yuting An, Chang Li, Xiaoyun Gong, Rui Zhai, Zejian Huang, Chunling Qiu, Xinhua Dai
Journal Article